Thermal Hazards of Synthesizing a Grignard Reagent under Different Dosing Rates

Thermal safety during the synthesis of a Grignard reagent under different dosing rates was evaluated in this work. A reaction calorimeter (SIMULAR) used to investigate heat release isothermal experiment range 0.5–2.0 g⋅min−1 rates. The thermal decomposition analyzed using accelerating rate calorimetry (ARC). Furthermore, risk assessment runaway matrix and Stoessel criticality diagram. results indicate that decreasing can decrease level synthesizing from class 3 1. However, at when induction period considered. In case cooling failure, most hazardous moment period, followed by period. These findings provide further evidence dose 0.5 safer produce reagents.